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The incident happened in the 12000 block of SH-99 at Huffsmith and Kohrville in north Harris County, Sheriff Ed Gonzalez tweeted.
One person has been confirmed dead, according to officials.
ABC13's SkyEye flew over the scene and saw traffic at a standstill with only one lane open for drivers to use.
A car was also seen with severe damage on both ends as officials began to clean up.
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In addition to the eastbound lanes, the eastbound ramp on SH-249 is closed as there is an active investigation ongoing.
Officials did not elaborate on how the crash happened.
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