To soften the blow, Tigers fans, Texas Southern did not make history Friday night.
The scrappy SWAC tournament champions were outmatched against No. 1 Xavier, which held the Tigers to minutes and minutes of scoring droughts in a 102-83 win.
For their part, the Tigers had five players scoring in double digits, led by Demontrae Jefferson's 20 points.
Derrick Bruce added 18 points and Robert Lewis scored 14.
A bright spot for the Tigers came at the 12:22 mark of the first half when TSU was up by 7 points. The elation was short lived when Xavier went on a 36-17 run into halftime.
TSU was the only team in the tournament with a losing record, but added a feather in the cap, winning its first NCAA Tournament game in school history.