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At about 4:45 p.m. Thursday, police received a call about a shooting in the 2100 block of 20th Avenue.
Police said it's unconfirmed if the woman was in the car alone at the time of the shooting, or if anyone else was inside.
With little information, police are asking witnesses to come forward.
Anyone with information on the woman's killing is urged to call Detective L. Williamson at 409-933-2151 or the Mainland Communities Crime Stoppers at 409-945-8477.