Deputies with the Harris County Sheriff's Office said they responded to a car crashing into a home in the 15400 block of Lucky Star near George Bush Park at about 10:15 a.m.
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When deputies arrived, they found the driver, a male in his late teens, with a gunshot wound.
Investigators told Eyewitness News the teen was sitting in his car when two suspects attempted to rob him and shot him when he refused.
According to deputies, he tried to drive away but crashed into the house with people inside.
The teenager was flown to the hospital in critical condition, but was pronounced dead hours later, Sheriff Ed Gonzales tweeted.
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Investigators described both suspects as Black men, wearing dark clothing.
One suspect had dreadlocks and the other suspect did not, according to deputies.
The investigation is ongoing.