Police were called to the halfway house in the 6000 block of Hogue Street around 3:31 p.m. Saturday.
According to investigators, a resident said two others were bullying him and he felt threatened.
He pulled a knife and lunged at them. The suspect admitted that he stabbed the two victims in self-defense, police said.
Police think the altercation may have been over food in the home.
The suspect and another victim were taken to a local hospital.