St. Thomas finished the season with a record of 5-5, but won four straight games to go undefeated in district, securing a playoff spot.
Scoring started early, with the Panthers returning the opening kickoff 102 yards for the score and an early 7-0 lead.
Eagles quarterback Peyton Matocha found Jordan Augustine in the end zone to tie the game, but St. Pius fired back just two minutes later, going up 14-7.
The Panthers managed to take a 21-13 lead into halftime, but were unable to hold on in the second half.
St. Thomas scored 21 unanswered points to take a commanding 35-21 lead midway through the third quarter.
The Panthers managed to cut it to a three point game with 4:44 left in the game, but couldn't complete the comeback as St. Thomas claimed the rivalry win and the district championship.