Angelina "Frances" Lopez was last seen in the 10000 block of Forum West Drive in southwest Houston, according to police.
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Lopez' brother spoke with Eyewitness News on Sunday and said no one has heard from her since mid-October. He said her close friends also haven't heard from her and say it isn't like her not to respond.
Lopez is being described as a 6-foot-1-inch Hispanic woman with light skin, brown eyes and black hair.
Police say she has a tattoo with the words "RIP Donna" on the left side of her chest. She also has flat feet, according to police, which may make her walk slowly.
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In addition, Lopez has scars on her lower back due to surgery.
If you have any information about Lopez, you're asked to call the Houston Police Department Missing Persons Unit at 832-394-1840 and reference NIC #M506016620.