George Springer became Houston's first player since Terry Puhl in 1980 to lead off the first game with a home run.
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Carlos Correa homered and drove in two runs as Houston won on opening day for the fifth straight year.
Keuchel (1-0) went 9-12 with a 4.55 ERA last year after winning the AL Cy Young Award in 2015. Winning on opening day for the third year in a row, he struck out four. Giles allowed a hit and Giles walked one with three strikeouts for the save.
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Felix Hernandez (0-1), making his 10th opening day start, allowed two runs and five hits while striking out six in five innings before leaving with tightness in a groin.
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Mariners and Astros eyeing playoffs on Opening Day
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