The Southwest Freeway at the I-610 West Loop is closed in both directions until 5 a.m. on Monday.
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There are detours that drivers can take, like Richmond Avenue, but it will be best to avoid the area throughout the weekend.
The closures are necessary as crews work to demolish more of the older I-610 Loop bridge that remains.
The construction which began in 2017, is entering its fifth year.
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The project is reportedly adding capacity to the interchanges by making two lanes ramps and adding shoulders to the West Loop bridge.
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Completion of the remodel is estimated to be in 2024.
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