It happened in the 5500 block of South Shaver St. around 12:45 a.m.
Police said they found a car about 100 yards from a Pemex gas station, where there was a struggle to arrest the man in the parking lot.
The man was rushed to the hospital where he later died. It wasn't clear what exactly happened or how the man died.
ABC13 has reached out to HPD for further comment.