On Sunday at about 10 p.m., HPD officers responded to a shooting at 2000 Smith St., where they found a man with multiple gunshot wounds.
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Paramedics transported the man to Ben Taub Hospital, where he was later pronounced dead.
Police said they received a 911 call from a nearby location where the possible shooter had reported the shooting.
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Once police arrived, police took the 21-year-old into custody and found the gun that was used in the shooting.
In a preliminary investigation, the gunman had just left a restaurant when he realized another man was following him, according to police.
The man who followed him was carrying an ice pick as he approached him at a crosswalk.
Police say the armed man fired his gun and shot the suspect after thinking he was going to rob him.