Police responded to reports of a wrecked vehicle on 610 South Loop around 12:45 a.m.
According to authorities, a witness spotted smoke coming from a vehicle and called police.
Investigators say a man in his mid or early 20s was driving westbound near Main Street when bullets started flying.
The man was shot multiple times, and found dead on the side of the road.
No arrests have been made.
Follow Katherine Marchand on Facebook and Twitter.