The Harris County Sheriff's Office said the wreck happened on the southbound lanes of SH-99 at Franz Road Wednesday evening.
Deputies said one man was taken to the hospital by Lifeflight, and a juvenile was driven by ambulance.
The man who was flown to the hospital is said to be in fair condition.
It is unclear what caused the wreck, and there were no other reported injuries. Drivers are being diverted off of the freeway at the Franz Road exit.
Deputies said the Texas Department of Transportation is at the scene and investigators are expected to clear the road by 5 p.m.
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