The shooting happened at about 1:45 a.m. on Saturday at a business on Hiram Clarke and Town Plaza Drive.
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Detectives with the Houston Police Department said the security guard who works at the establishment was shot twice during a disturbance with the suspect(s).
The victim was taken to the hospital and is in stable condition, police said.
Police believe the security guard was unarmed and did not exchange gunfire.
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Investigators are looking into nearby surveillance video and have not released a description of the suspect(s).