The accident happened at about 7 a.m. on the South Loop east feeder road near the I-45 Gulf Freeway at Berkley in southeast Houston.
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HISD said bus route 2102 was on its way to a nearby campus at the time of the crash.
The school bus was on the feeder road, trying to make a sharp right turn onto Berkley, when a car hit the bus, causing it to flip onto its side, Houston police said.
The Houston Fire Department said 10 children and two adults -- the bus driver and the driver of the other car involved in the crash -- were taken to the emergency room with minor injuries. Everyone managed to get out of the bus on their own and waited for first responders to arrive.
The students attend High School Ahead Academy Middle School, the district said.
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HPD said everyone was taken to the hospital out of precaution. No serious injuries were reported.
SkyEye flew over the scene as crews worked to upright the bus and clean up the mess. The video shows a lot of damage at the bottom of the bus, as well as some fluid leakage.
The I-610 South Loop feeder road eastbound was closed for a short period while the bus was towed away, but has since reopened.
An investigation is underway to determine which driver was at-fault.
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