The Harris County Sheriff's Office responded to the accident on Will Clayton Parkway near Timber Forest Drive around 12 p.m.
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An Eyewitness viewer snapped pictures of the scene, showing multiple people being transported to an ambulance on a stretcher.
Authorities say the bus driver and bus aide were transported to the hospital with minor injuries. The condition of the driver in the BMW is unknown.
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Officials told Eyewitness News that no kids were on the bus during the time of the incident.