Police were searching for two men who were wanted for questioning in connection to the deadly shooting.
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The suspects have been identified as Joe Allen Lewis, 21, and 19-year-old Lynn Johnson.
On Saturday at 12:38 a.m., Huntsville Police Department officers responded to a shooting at a large house party near 19th Street and Avenue O.
When police arrived, multiple victims were found at the scene, and lifesaving efforts immediately began, according to authorities.
Four victims were reportedly transported to area hospitals for treatment.
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One of the victims succumbed to their injuries and was pronounced deceased at the hospital, according to police.
The other three victims were listed in critical condition.
Lewis has been charged with aggravated assault with a deadly weapon, and Johnson was charged with assault.
Police have said more charges are expected soon for both.