The crash happened at about 9 a.m. on Sunday on the southbound lanes at 16837 North US-59 at Rankin, HPD said.
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Two vehicles involved were said to be a gray Ford F-150 and a white Sedan.
According to reports, an 18-wheeler hit two stalled vehicles on the freeway.
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There was no word on fatalities, but HPD said they had reports of multiple injuries and entrapment.
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