Harris County sheriff's deputies say it happened on Blue Bell Road near Veterans Memorial just after 10 p.m. Wednesday.
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The woman fired at least 20 shots, but the 19-year-old man was only hit once, deputies say.
Deputies applied a tourniquet to the man's leg at the scene. He is expected to survive.
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According to Captain J. Shannon, deputies located the suspect hours after the shooting and took her into custody.