Robert Isaac and Willie Sims, both 34, were killed late Sunday at 1100 Dennis Street near the Fannin Street intersection around 11:15pm.
Eyewitness News cameras were there Wednesday afternoon as community activist Quanell X escorted a transgender woman into Houston Police Department headquarters.
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Quanell X says what happened was not a hate crime.
"This is not a hate crime, she was not attacked for her gender," he said. "This has everything to do with drugs, prostitution and a whole lot of criminal activity where this unfortunate tragedy took place."
Police have not made any arrests in the case and no charges have been filed.