Rosario Cano, spokeswoman for the interior department of the northern state of Coahuila said 10 people had been confirmed killed so far in the twister, which struck around 6:40 a.m. Central time.
Photos from the scene showed cars with their hoods ripped off, resting upended against the facades of one-story houses.
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One car's frame was literally bent around the gate of a house.
A bus was seen flipped and crumpled on a roadway.
Ciudad Acuna is a city of about 100,000 across the border from Del Rio, Texas.
Cano said top state officials had set out to review the damage and coordinate response to the disaster.