Alize Yasmine Mendez, 16, and Xavier Alfonso Mendez, 15, have both been missing since April 16 and were seen in the 900 block of Baker Drive.
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Police say Alize, who goes by Zay, has been seen since she left, but her brother has not.
Alize was wearing a black shirt, black pants and black Nike Air Force 1 shoes. She wears her hair straight, wavy or sometimes in a bun. She has long hair that hits a little past the middle of her back. Alize has her ears and belly button pierced.
Alize is described as a Hispanic female, 5'2", 120 pounds with brown hair and brown eyes.
Xavier was wearing black sweats and a black shirt. He has brown eyes, wavy hair and pierced ears. He is described as a Hispanic male, 5'1" - 5'2," and weighs 130 - 140 pounds.
According to police, both siblings went to Alief Taylor High School, where Alize was in the 10th grade and Xavier was in the 9th.
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The siblings' family is concerned for their safety.
If you see them or have information, you're asked to contact Sergeant Smith at 281-290-1315.
Police now believe the siblings could be in the Houston, Fort Bend, Alief, Cypress, Katy, Bear Creek, or Aldine areas.