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According to the Houston Police Department, the crash happened at around 10:40 p.m.
Police say South Houston PD was initially chasing a motorcyclist for traffic violations, but called off the pursuit after three minutes.
Officers say the motorcyclist went over the guardrail at a high rate of speed and landed on the southbound lanes of I-45.
Police officers and fire officials began life-saving measures, but the motorcyclist was later pronounced dead at the scene.
The identity of the motorcyclist has not been disclosed.