Missouri City said fire and rescue teams responded to the scene near Highway 90 and Cravens Road.
No injuries were reported.
Officials said there was no train derailment or hazardous materials released.
SEE PREVIOUS REPORTING: Missouri City leaders consider road changes to reduce train collisions at US-90A
Cravens Road was closed as crews worked to remove the 18-wheeler and clear the scene, authorities added.
It's unclear at this time what may have led to the collision.