The crash happened in the 9600 block of the Southwest Freeway.
According to the Houston Police Department, a driver of a BMW was traveling eastbound at a high rate of speed on the freeway and collided with the motorcyclist.
Police say the suspect got out of his vehicle and walked away from the scene.
A witness who followed the suspect told police that the suspect entered an IHOP parking lot and jumped a fence when he noticed he was being followed.
The suspect is described as a light-skinned Hispanic male in his early 20s, wearing a black shirt and shorts, HPD said.
According to police, the BMW was taken for further evidence.
An investigation is ongoing.