The ramp was blocked during the morning commute and reopened at about 10:20 a.m.
ABC13's Courtney Carpenter was at the scene earlier in the morning, where you could see the 18-wheeler on its side and hazmat trucks responding to the site.
It wasn't immediately known if there were any injuries.
Traffic moved again quickly after the crash cleared.
I-610 North Loop WB exit ramp at I-45 blocked after 18-wheeler crash
ABC13 has real-time traffic data to help you navigate Houston's roads and avoid traffic delays.
Sign up for traffic alerts sent straight to your phone through our ABC13 app. Manage your notifications from the settings tab.
[Ads /]
On mobile, use two fingers to zoom in to specific roads.
Live traffic map