The incident was reported just after 2 a.m. on SH-99 Lanier/Grand Parkway westbound near the San Jacinto River bridge. All westbound lanes were closed until about 9:05 a.m.
Drivers were asked to avoid the area between Riley Fuzzel and FM 1314, but the crash has since cleared.
Authorities have not said what led to the crash or whether there were any injuries.