Harris County Sheriff Ed Gonzalez said the crash happened near IH-610 East at the Kirkpatrick exit.
Gonzalez said the suspect was believed to be in a stolen car when he slammed into the Harris County Sheriff's Office truck.
SkyEye was above the scene, where a heavy police presence could be seen. Eyewitness News saw the deputy's truck appear to have damage on one side, and crews were towing away the stolen vehicle.
The suspected driver and his passenger, who are 17 and 18 years old, were detained, according to the sheriff. Gonzalez said the deputy has minor injuries but is expected to be OK.