U.C. Merced sent an alert Wednesday morning warning students stay away from the COB as there had been a stabbing inside the building.
University of California, Merced, spokeswoman Lorena Anderson said Tuesday that two of the victims were taken by helicopter to hospitals for treatment. She said the three other victims were treated locally.
Anderson says the school remains on lockdown and classes have been canceled for the day.
Officials said the stabbings occurred shortly before 8 a.m. PST Tuesday.
The rural school is about 120 miles south of Sacramento.
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The Associated Press contributed to this report.