According to the Montgomery County Fire and Rescue Service, first responders were dispatched to the scene in Silver Spring just before midnight Wednesday.
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The department said early Thursday morning that the fire was believed to be under control.
Capt. Oscar Garcia tells The Associated Press the two firefighters injured are believed to have injuries that are not life-threatening. The extent of the others' injuries wasn't immediately known.
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Garcia says not everyone is yet accounted for. The fire involved at least two or three buildings.
The department tweeted photos that showed a building at least partially collapsed and rubble strewn on the street in front of it.