Houston TranStar cameras showed the truck's trailer tipped over on the barrier separating the I-10 East and Uvalde Road roadway.
Skyeye was over the scene as crews worked to move the truck's cab.
Officials did not specify when the clean-up would be finished, but drivers could expect it to be there for a while.
ABC13 traffic maps showed the crash has significant impact on both sides of the roads as crews began the process of removing the heavy-duty vehicle.
It it unclear how the crash happened or if there were any injuries.
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