According to the Houston Fire Department, units responded to a building on El Camino Real shortly before 7 a.m.
ABC13's SkyEye flew over the scene and saw heavy smoke and flames as it approached.
Signs on the building engulfed in flames indicated it was Molly's Pub.
After about 30 minutes of firefighters trying to contain the blaze, the building's roof caved in.
It is unclear if any employees were in the building or if there were any injuries.
ABC13 is seeking additional information and will bring you the latest updates on Eyewitness News, streaming on Monday morning.