The crash happened in the 16900 block of Shrub Oak Drive, between the Atascocita Acres and Atascocita Forest subdivisions, according to the Harris County Precinct 4 Constable's Office.
Two of the injured were taken by ambulance; a third declined treatment, officials said.
Atascocita Fire Department, Precinct 4 deputies, and Humble Fire Department medical units all responded.
This is a developing story. Eyewitness News is continuing to gather facts.