Officers responded to the shooting at a convenience store at 4700 Lockwood on Friday evening, where they found a woman unresponsive in the driver's seat of a vehicle.
Detectives say that the woman drove to the location with her husband as a passenger. According to authorities, the woman's husband went into the store, where an employee asked him to leave. When the husband left the store, a man fired shots into the vehicle as he was about to leave the parking lot, police said. Law enforcement says that the woman's husband exited the vehicle and ran, which is when a second man fired shots at him.
Authorities say that the two male shooters fled on foot.
The woman's husband was not injured, according to officials. In addition, there were two other family members in the backseat of the vehicle who were not hurt, police said.
The woman, who was hit, was later pronounced dead at a hospital.
The identity of the 45-year-old woman is pending verification by the Harris County Institute of Forensic Sciences.
Police said the two suspects haven't been caught.