The League City Police Department said that four were taken to a hospital while two were treated by EMS and later released.
Officials said investigators have been at the 3100 block of S IH-45. Drivers are being diverted to take the FM 517 exit.
League City PD said the dense fog may have been a factor in causing the crash. Officials said at least eight cars were involved.
The crash has since cleared.
ABC13 has real-time traffic data to help you navigate Houston's roads and avoid traffic delays.
[Ads /]
Sign up for traffic alerts that are sent straight to your phone through our ABC13 app. Manage your notifications from the settings tab.
Live traffic map