SkyEye13 video captured crews working to clear the incident, which is blocking two lanes of I-69 southbound near Lee Road.
In the video, the truck cab and a pickup truck above it appear to be heavily burned as well as several other vehicles right behind the cab.
Houston TranStar reported the vehicle fire just before 6 a.m.
It's unclear what may have led the truck to ignite or whether any injuries were reported.
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