A group left around 9 a.m. to pick up 15 cats and kittens to keep safe in Houston until the storm clears.
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The transport allows the animal protection organization to focus on emergency services during and after the hurricane.
They also helped evacuate more than 200 animals before Hurricane Laura's impact in August.
SEE RELATED STORY: Houston SPCA evacuates hundreds of animals before Laura's landfall
While Louisiana is bracing for Delta's impact, evacuations happened for people in Mexico.
It was a mad scramble inside an airport in Cancun Tuesday as passengers tried to book last minute flights to get out of the storm's path.
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For those who decided to stay behind, evacuations to makeshift shelters took place.
Conference rooms were filled with rows of beds to accommodate resort guests who chose to stay.
A plane full of Houstonians coming from Cancun landed Tuesday, and one couple on their honeymoon said they spent about $5,000 on flights to return home.
SEE RELATED STORY: Honeymooners forced to pay $5,000 for flight back to US ahead of Hurricane Delta