The man was trying to cross the main lanes of the East Freeway near the East Loop around 10:30 p.m. Thursday when he was hit, police said.
Police found the man lying on the eastbound ramp onto Highway 90. He was pronounced dead at the scene.
Investigators believe he was hit by one or two vehicles. The driver(s) who hit him did not stop.
Police did not have a description of the wanted vehicles.
Anyone with information is asked to call the HPD Vehicular Crimes Division at 713-247-4072.