The crash happened around 3:40 a.m. Monday. Highway 6 northbound between Westpark and Richmond was closed as officers investigated the deadly crash. It has since reopened.
Houston police said an Amazon Prime truck hit and killed a man who was standing in the middle of the roadway.
The pedestrian was pronounced dead at the scene.
That stretch of Highway 6 is dark in the area, investigators noted.
The Amazon driver stopped at the scene and was cooperating with police, investigators said.
Police said it's unclear why the pedestrian was standing in the middle of a moving lane of traffic.