He was hit around midnight by a driver in a White Nissan, Houston police said.
The crash caused the pedestrian to flip over the vehicle, investigators said. That's when he was hit by a second vehicle.
Paramedics with the Houston Fire Department pronounced the man dead at the scene.
The driver of the Nissan showed signs of intoxication and was taken into custody, HPD said.
The Harris County District Attorney's Office will determine if any charges will be filed.
Investigators said it's unclear why the man was trying to cross the freeway.