The crash happened on Highway 35 and North Columbia Drive.
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ABC13's SkyEye was at the scene and saw emergency vehicles and officials inspecting a white pickup truck and another vehicle on opposite sides of the road that had suffered damage.
The white truck's front end appeared to be severely damaged.
The second vehicle, a burgundy-colored truck, sustained damage to the front windshield,and the tailgate and is missing a tire.
According to officials, the driver of the white F-150 pickup was driving northbound on SH 35 when the second vehicle, a maroon F-250, traveling southbound, ran a stop sign, pulled out in front, and collided with the white truck.
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Upon impact, officials said the driver and passenger of the F-150, a 61-year-old woman and a 90-year-old, ejected from the car and into the grassy median.
Neither the passenger nor driver were wearing seatbelts, officials said.
The white pickup driver sustained minor injuries but refused transport by EMS.
The status of the driver and the passenger who was ejected is unclear.