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The crash was reported at 5:21 a.m. on the East Freeway at Eastex going eastbound, according to Houston Transtar.
The right shoulder, right lane, center lane and the entrance ramp are all closed, still two hours after the incident.
SkyEye video shows traffic backed up all the way to Heights Boulevard.
Drivers are instead urged to take I-45 southbound to the 610 South Loop and then head over to I-10.
ABC13 has real-time traffic data to help you navigate Houston's roads and avoid traffic delays.
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