The wreck was reported at about 10 a.m. near Rice Road, east of Bradbury Road, according to the Waller County Sheriff's Office. The roadway was reopened just before 2 p.m.
SkyEye flew over the scene, where the large truck could be seen overturned on the side of the bridge.
Officials said there was a cement spill and fuel from the truck, so hazmat crews worked to clean it up. A road crew also inspected the bridge for any damage once the truck was removed.
No injuries were reported.