The teen is in critical condition after what police described as a "traffic altercation" that happened around 8:30 p.m. along W Montgomery Road.
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Lt. Larry Crowson with Houston police said a woman and three teens, ages 14, 15 and 16, arrived at an emergency room in the 500 block of West Tidwell shortly after. The woman's foot was grazed by a bullet, but the 14-year-old girl had several gunshot wounds, according to police.
"It was some kind of a traffic altercation that led to a shooting," said Crowson.
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The girl was transported to the hospital by Life Flight where she remains in critical condition.
Meanwhile, the 15- and 16-year-old were not hurt. The woman is expected to recover.
Crowson said officers are working to get more information. A description of the suspect or suspects was not yet immediately released.
The incident remains under investigation. Anyone with information is urged to contact police.