The shooting happened on Dec. 14 at about 5 a.m. at 191 West Road, where deputies said they found a 37-year-old man with a gunshot wound to his head.
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Officials said that the victim was driving along the southbound lanes of I-45 near Rankin Road.
The suspect was driving a white 2007-2013 Chevrolet Silverado four-door pickup when he pulled up alongside the victim and allegedly shot him in the head.
Investigators said the victim was alert and awake while being taken to a nearby hospital.
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The suspect is described as a white man, 40 to 50 years of age, with a full beard and mustache. He was also wearing a unique baseball cap with little badges that said "veterans" on it.
It is unclear what led up to the shooting.
Authorities urge you to contact the Harris County Sheriff's Office Violent Crimes Unit at 713-274-9100 or Crime Stoppers at 713-222-TIPS (8477) if you have any information related to this investigation.
Information leading to the charging and/or arrest of any felony suspects may result in a cash payment of up to $5,000. Tipsters must contact Crime Stoppers directly to remain anonymous and to be considered for a cash payment by calling 713-222-TIPS (8477), submitting an online tip, or through the Crime Stoppers mobile app.