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There will be crushing defeats and inspiring victories, Cinderella stories and dominant performances, and enough excitement to keep even cursory basketball fans glued to the television.
So with all of this action, how can you keep up with it all? Here's a schedule with what to expect Sunday and in later rounds.
Related: How to build your bracket for this year's NCAA tournament
Sunday, March 31
2 p.m. (CBS): #5 Auburn vs. #2 Kentucky
4:55 p.m. (CBS): #1 Duke vs. #2 Michigan State
Saturday, April 6
6 p.m. (CBS): Final Four
8:30 p.m. (CBS): Final Four
Monday, April 8
9 p.m. (CBS) NCAA National Championship Game