The crash happened around 7:20 p.m. Friday in the 11700 block of Spring Cypress.
Harris County sheriff's deputies said the motorcyclist was traveling eastbound while a white Nissan Altima made a U-turn from the westbound lanes.
The motorcyclist wasn't able to stop in time and slammed into the Nissan, deputies said. Investigators believe the motorcyclist was speeding at the time of the crash.
The motorcyclist, who was pronounced dead at the scene, is described as a 31-year-old Hispanic man. Investigators said he was wearing a helmet.
The driver of the Nissan failed to stop and render aid and fled the scene, deputies said. Investigators believe the Nissan Altima should have damage to the back end.