The Houston Police Department said one person died when the collision happened just before 7 a.m. on Homestead Road near East Mount Houston Road.
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SkyEye flew over the active scene, where a heavily damaged SUV and motorcycle could be seen in the intersection.
Authorities urged drivers to avoid the area.
HPD's vehicular crimes division is investigating the deadly crash.
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It's unclear how the crash unfolded or if any other injuries were reported.