It happened around 12:20 a.m. at a home in the 10100 block of Sagedale Drive.
A 37-year-old woman was reportedly shot several times by her 20-year-old son, identified as Jacob McMurrough, according to Harris County deputies.
The two got into an argument and the woman's son got a gun out of a car and opened fire, investigators said.
The mother and son lived with the mother's parents, who are in their 90s and were home at the time.
McMurrough was booked into the Harris County Jail Saturday morning on a murder charge.
Follow Mycah Hatfield on Facebook and Twitter.