Around 4 a.m., officers responded to a home in the 9500 of Fairfield Street near Sparrow after reports of a shooting.
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Lt. Wilkins with HPD said the mother and son got into an argument after the son reportedly wrecked her car.
At one point, the son reportedly attacked his mom, causing her to retrieve a gun and shoot him in the leg, according to HPD.
Houston Fire Department officials arrived and transported the man, whose condition is unknown, to the hospital.
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An investigation is underway.